Interactive macromolecular sites. I. Basic theory.
نویسنده
چکیده
A general theory of the evolution of interactive surfaces or sites on cell macromolecules is presented based on the assumption that all macromolecules present in cells are covered with reactive groups to which counter sites can theoretically be made. Initially such potentially reactive sites are considered to exist in pairs. Once one member of a pair is incorporated into a cell, its opposite number is forbidden except where it may be employed to advantage for structure formation. As more and more potentially interactive sites appeared in cells during evolution, a limit was approached where one member of each pair was present. Such a limit has been termed a perfect set, and would both define a “self” and recognize foreignness. The role of perfect sets in the development of the immune system, in differentiation, and in so-called random fixation of amino acid sequences is reviewed.
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عنوان ژورنال:
- Journal of theoretical biology
دوره 60 2 شماره
صفحات -
تاریخ انتشار 1976